That same year, she dominated the Pan American Games in Toronto, earning two gold medals in both the 400 metres hurdles and the 4 × 400 metres relay, and later secured a silver medal in the 400 metres hurdles at the 2015 World Championships in Beijing. Transitioning to her professional career, Little continued her national dominance by winning the USA Outdoor Track and Field Championships in the 400 metres hurdles in 2015 and again in 2018. She further solidified her international standing in 2018, claiming a gold medal in the 400 metres hurdles at the NACAC Championships. Her prowess on the global circuit was evident as a multiple Diamond League circuit winner, with notable victories in highly competitive events across Zürich, Lausanne, London, and Rabat.
In July 2021, Little delivered a career-defining performance, setting a personal best of 52.39 seconds in the 400 metres hurdles, positioning her as the fifth-fastest woman of all time in the event. She reaffirmed her status as a national champion in 2023, securing her third USA Outdoor Track and Field Championships gold medal in the 400 metres hurdles. The same year, she earned another prestigious silver medal in the 400 metres hurdles at the 2023 World Championships held in Budapest. Most recently, Little achieved significant Olympic success at the Paris Games in 2024.
She was a pivotal member of the United States team, earning a coveted gold medal in the 4 × 400 metres relay. Additionally, she secured a silver medal in the fiercely contested 4 × 400 metres mixed relay, further cementing her position as one of the world’s leading track and field sprinters.