He was drafted second overall by the Portland Timbers in the 2011 MLS SuperDraft, immediately making an impact and earning the MLS Goal of the Year award in his debut season. During his tenure with the Timbers from 2011 to 2017, Nagbe became a central figure, contributing to their first MLS Cup victory in 2015. His consistent professional conduct was also recognized with MLS Fair Play Awards in 2013 and 2015, and he was named an MLS All-Star in 2016. Nagbe continued his decorated career by joining Atlanta United FC for the 2018 and 2019 seasons, where he secured his second MLS Cup title in 2018.
With over 440 regular season appearances, Nagbe ranks among the top players in MLS history for minutes played and fouls sustained, a testament to his persistent involvement and durability. He is also a member of the elite MLS 400 Games Club. In 2024, Nagbe was recognized for his significant community engagement, receiving the prestigious Audi Goals Drive Progress Impact Award. Following a career celebrated for both individual skill and profound contributions to team success, Nagbe announced his retirement will take place after the 2025 MLS Cup Playoffs, marking the conclusion of an era for one of Major League Soccer’s most consistent and decorated midfielders.