Jessie T. Usher Jr. established himself in television with guest appearances on series such as Without a Trace, Numbers, The Mentalist, Criminal Minds, Lincoln Heights, Hannah Montana, and Summer Camp between 2005 and 2009. A significant turning point in his early career came in 2011 when he secured the lead role of Lyle Hugginson in the Cartoon Network television movie Level Up.

In 2019, Usher took on the pivotal role of John Shaft Jr. (JJ) in Netflix’s Shaft. The same year marked the beginning of his portrayal of Reggie Franklin / A-Train in the critically acclaimed Amazon series The Boys, a role he continues to embody. Expanding his filmography, he starred opposite Camila Mendes in the Netflix film Dangerous Lies (2020) and appeared as Tony in Apple TV’s The Banker (2020).

Usher’s recent work includes voicing Quinn in Seal Team (2021) and starring as Trevor in the Paramount psychological horror film Smile (2022). He further diversified his portfolio portraying Davon in Tales of the Walking Dead (2022). In 2023, he reprised his iconic role of A-Train in the Amazon spin-off series Gen V and lent his voice to the character for Call of Duty: Modern Warfare III. Looking ahead, Usher is set to take on the main role of Sam Elijah in the upcoming series Pulse, slated for release in 2025.