Sistine Stallone established her presence in the fashion industry, signing with IMG Models in 2016 and quickly securing high-profile appearances and editorial features. Her early career highlights included walking in a Chanel fashion show in 2016 and being featured in the July 2016 issue of Glamour magazine. Stallone further solidified her modeling profile in November 2017 when she graced the cover of Elle Russia. Her visibility extended into broader entertainment in January 2018, when she was honored as a Golden Globe Ambassador at the 75th Golden Globe Awards.
Demonstrating her growing creative versatility, she has also expanded into screenwriting, with a horror film titled Scavenger Hunt currently in pre-production, for which she holds a coveted writer credit. Stallone continues to pursue new projects across film and television, actively adding to her acting repertoire. This includes an upcoming acting role as Ruth in the film Bad News on the Doorstep, which is presently in post-production. Her multifaceted approach to her career, spanning successful work in acting, modeling, writing, and podcasting, underscores her strategic development as a dynamic and versatile talent within the entertainment industry, making her highly marketable for diverse roles and projects.