He subsequently transferred to Mississippi State, where he played in 26 games with 23 starts during the 2012 and 2013 seasons. As a Bulldog, Autry accumulated 73 total tackles, 16 tackles for loss, six sacks, and three forced fumbles. Autry continued to build his career with the Oakland Raiders, demonstrating consistent defensive prowess. In 2018, he secured a significant three-year, $17.8 million contract with the Indianapolis Colts.
During his tenure with the Colts, he notably recorded a career-high three sacks and two forced fumbles in a single game against the Jacksonville Jaguars in 2018, an achievement that earned him the AFC Defensive Player of the Week recognition the same year. He consistently proved to be a pivotal force on the defensive line, elevating his reputation in the league. In 2021, Autry signed a three-year, $21.5 million deal with the Tennessee Titans, where he further solidified his status as an elite pass-rusher. The 2023 season marked a career highlight, as he led the Titans with a personal best of 11.5 sacks and recorded 58 quarterback pressures.
His remarkable consistency during this period made him the first Titans player since Jevon Kearse (1999-2001) to record eight or more sacks in three consecutive seasons, underscoring his sustained impact and formidable presence on the field. Building on his impressive track record, Denico Autry commenced the 2024 season by signing a two-year contract with the Houston Texans. An accomplished NFL defensive end, Autry continues to be recognized for his consistent pass-rushing abilities and significant contributions across multiple teams throughout his distinguished professional career, solidifying his reputation as a highly sought-after talent in the league.