His exceptional performance for the Buffalo Bulls, where he earned third-team all-conference honors in 2010 and first-team All-MAC honors in 2011 and 2012, led to him being the highest-selected Buffalo player ever in the NFL draft. Mack was chosen fifth overall by the Oakland Raiders in 2014, quickly making an impact by finishing his rookie year with 76 combined tackles and four sacks. In 2015, Mack made history by becoming the first NFL player to be selected first-team All-Pro at two different positions in the same season: defensive end and outside linebacker. He further solidified his elite status in 2016, winning the prestigious NFL Defensive Player of the Year award after recording 73 tackles, 11 sacks, five forced fumbles, and an interception returned for a touchdown.

Maintaining his high level of play, Mack was traded to the Los Angeles Chargers in 2022, immediately stepping into a pivotal role as a key defensive player for the franchise. In 2023, Mack delivered a career-defining performance, recording an impressive six sacks in a single game, tying a Los Angeles Chargers franchise record. Demonstrating his longevity and impact, he also recorded his 100th career sack during the 2023 season, cementing his legacy as one of the league’s most formidable pass rushers. As a veteran leader for the Chargers, Mack continues to be an integral part of their defense, contributing his exceptional skills and leadership to the team’s ongoing efforts.