Supriya Ganesh made her screen debut on the CBS series Blue Bloods in 2018, launching a diverse career across television, film, and theatre. Shortly after her debut, Ganesh was selected for the prestigious ABC Showcase, a program renowned for recognizing and elevating emerging talent within the industry. This early recognition quickly led to a series of notable television appearances, including roles in The Enemy Within and The Village, both released in 2019, solidifying her presence in the competitive landscape of network television. Ganesh continued to build momentum with an appearance in New Amsterdam in 2021.

The following year, 2022, proved to be a pivotal period, seeing her cast as Pamela in the film Pinball: The Man Who Saved the Game. That same year, she made an appearance in Law & Order: Special Victims Unit and was featured in Everything’s Trash. Her career progressed steadily into 2023 with a role in Chicago Med and a guest starring role as Alexis in a 2023 episode of Billions. She also secured a recurring role in the popular series Grown-ish, appearing from 2023 to 2024.

Currently, Ganesh is critically acclaimed for her main role as Dr. Samira Mohan in HBO Max’s medical drama, The Pitt, which premiered in 2025. This character has brought her widespread attention, with the series achieving significant viewership on the platform. Leveraging her academic background in neuroscience, Ganesh’s nuanced portrayal of medical professionals has resonated deeply with audiences and critics alike, enhancing the authenticity of her performances in the genre.

In 2025, Ganesh further expanded her artistic range into theatre, starring as Vaidehi in the world premiere of Deepak Kumar’s House of India at the renowned Old Globe Theatre. Through her evolving body of work, Ganesh consistently engages with and contributes to broader conversations surrounding representation within the entertainment industry.